Owing to the globalization phenomena, International Economics and Politics aspects have extensively been debated amidst scholars of International Business given the extent of its impinge upon operational and strategic competitiveness scope of multinational enterprises. Conjoint with the regional reality of most trade and investment preferential agreements – which fosters rather a regional integration of markets, as opposed to a much suppositional “global” market – globalist-approach international business strategy theories have come under closer scrutiny. Whereas some scholar like Pankaj Ghemawat (2007) proposes “semi-globalization” theories because thereof; others, namely Alan Rugman and Alain Verbeke (inter alias 2004, 2007), on the other hand, vindicate stricter regionalist approaches in international business and international corporate strategies. Such upholds in the performance of transnational corporations, nonetheless, have not been comprehensively tested thereby leaving other relevant questions unanswered. As such we identified scantiness in the literature as to whether regions – rather than individual countries – are relevant to the overall performance of multinational companies and to what extent. In the light thereof we utilized a longitudinal quantitative methodology in order to asses historical evidence of the repercussion on transnational companies’ performance regarding their presence in selected regions and/or individual countries. We collected data from Compustat Global (2009) thereto and proceeded to econometrical panel data analysis. Our findings briefly consisted of threefold conclusion. First, when both variables (country and region) are simultaneously deemed to be influential, there is statistical significance. Second, when contrasting both variables (country and region) as to the higher impact on performance, albeit we found statistical relevance for countries individually, we suspected of problem in raw data. Third, when assuming a positive correlation between the multinational company performance and the number of geographical regions where they have significant operations, we found statistical significance. Our conclusion thus is once the majority of countries are signatories of at least one integration agreement; regions should be the main focus of international business and international corporate strategy for both theoretical (in view of the findings and the literature) and practical (rather than a one-by-one country approach) purposes.